Iota carrageenan amazon11/10/2023 īaba M, Snoeck R, Pauwels R, de Clercq E. Polysaccharides as antiviral agents: antiviral activity of carrageenan. Iota‐carrageenan as an antiviral treatment for the common cold. Carrageenans as broad‐spectrum microbicides: current status and challenges. Overview on the antiviral activities and mechanisms of marine polysaccharides from seaweeds. Pharmacology Research & Perspectives published by John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics. SARS-CoV-2 common cold iota-carrageenan meta-analysis quantile treatment effect randomized trial rhinovirus. Further research on nasal iota-carrageenan is warranted. Given that carrageenan has an effect on diverse virus groups, and effects at the clinical level on two old coronaviruses, it seems plausible that carrageenan may have an effect on COVID-19. 003) reduction in the risk of longer colds. In the placebo group, 21 patients had colds lasting over 20 days, compared with six patients in the carrageenan group, which corresponds to a 71% (p =. Carrageenan had no meaningful effect on shorter colds. The 13.7-day colds were shortened by 3.8 days (28% reduction), and 8.8-day colds by 1.3 days (15% reduction). The fifth quintile contained patients with censored data. The mean duration of all colds in the placebo groups of the first four quintiles were 4.0, 6.8, 8.8, and 13.7 days, respectively. The increase in recovery rate was 139% for coronavirus infections, 119% for influenza A infections, and 70% for rhinovirus infections. Nasal carrageenan increased the recovery rate from all colds by 54% (95% CI 15%-105% p =. ![]() We also used quantile regression to calculate the effect of carrageenan on colds of differing lengths. ![]() We used Cox regression to estimate the effect of carrageenan on recovery rate. In both trials, iota-carrageenan was administered nasally three times per day for 7 days for patients with the common cold and follow-up lasted for 21 days. In this individual patient data meta-analysis we examined datasets of two randomized placebo-controlled trials which investigated the effect of nasal carrageenan separately on children and adults.
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